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Simply put, greater working pressures tend to upset a fuel's stability (a cause of detonation), and the octane rating is a fuel's ability to resist detonation. That being said, there is a limit to what a fuel of a given octane will withstand.
What works for a given combination depends upon a number of factors, such as the efficiency of the turbo, the design of the piston and combustion chamber, valve timing, etc., and so forth. Will E100 work with 12.2:1 SCR and a large turbo at 40psi? Maybe so. One either has to consider what's been done by others and how successful that appears, or, be willing to venture into the unknown and discover the answer himself. It's a question that isn't easy to resolve with math.
In short, just remember that boost trumps SCR. That being said, where there is a question, I'd prefer to stay in a 'safe area' with the SCR and be generous with the boost.
As for making better power with lesser boost, that is probably more so a function of volumetric efficiency than SCR. There is a reason why Hondas with 340cfm heads seem to make big power with relatively little effort.
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